Dormant viral pathways underlie space-induced neural senescence: a neuroprotective strategy for spaceflight and neurological diseases
Aline Maria Araújo Martins, Hideyuki Nakashima, Ángela Macia, Taichi Umeyama, Satoshi Miyashita, Livia LS Nascimento, Luisa Bulcao Vieira Coelho, Pinar Mesci, Erik Viirre, Nicole Suarez, Aurian Saleh, Alex Savchenko, Beatriz Freitas, Aline de Lima Leite, Diego M. Assis, , Alysson Renato Muotri
The paper shows that spaceflight triggers neural senescence via reactivation of dormant viral-like retroelements, and that reverse transcriptase inhibitors can reverse these effects.
bioRxiv · Nov 2, 2025 · PreprintNeuroscience