Allele-agnostic KCNH1 suppression rescues gain-of-function developmental epileptic encephalopathy
Wanhao Chi, Erin E Corbett, Christopher H Thompson, Dina Simkin, Hiba Adil, Nicole A Hawkins, Noah A Callow, Levi Barse, Alfred L George, Jennifer A Kearney, Evangelos Kiskinis
This study shows that suppressing KCNH1 rescues seizures and developmental issues caused by gain-of-function variants in KCNH1.
bioRxiv · Nov 9, 2026 · PreprintNeuroscience