Wanhao Chi

This study shows that suppressing KCNH1 rescues seizures and developmental issues caused by gain-of-function variants in KCNH1.

This study investigates how genetic vitamin B6 deficiency interacts with alcohol consumption in Drosophila, showing altered behavior and metabolism, with potential therapeutic implications.

The paper analyzes the expression patterns of epilepsy-associated genes across tissues and brain cell types, revealing distinct expression-phenotype correlations among gene classes.

This study shows that PNPO variants in Drosophila interact with diet to produce diverse phenotypes, including seizures and lethality, and highlights the utility of a knock-in model for studying human PNPO deficiency.

This study identifies syp as a gene regulating Starvation-Induced Hyperactivity in Drosophila through RNA-binding protein function and alternative splicing.

This study establishes Drosophila models of PNPO deficiency, showing seizures and lethality linked to low PLP levels, and demonstrates functional conservation between human and fly PNPO.