Author

Dina Simkin

Northwestern UniversityORCID 0000-0002-4473-5960Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

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Research Focus:cell type annotation· 4 Organism:human· 3 Research Focus:differential expression· 2 Assay:electronic health records· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1

Frequent Co-Authors

Alfred L. GeorgeiD· 4 shared Evangelos KiskinisiD· 3 shared Linda C. Laux· 2 shared Marc P. ForrestiD· 2 shared Peter PenzesiD· 2 shared Brandon N Piyevsky· 1 shared Christopher H Thompson· 1 shared Erin E Corbett· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Alfred L. GeorgeORCID

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4 papers

Recent·Most cited

Allele-agnostic KCNH1 suppression rescues gain-of-function developmental epileptic encephalopathy

Wanhao Chi, Erin E Corbett, Christopher H Thompson, Dina Simkin, Hiba Adil, Nicole A Hawkins, Noah A Callow, Levi Barse, Alfred L George, Jennifer A Kearney, Evangelos Kiskinis

This study shows that suppressing KCNH1 rescues seizures and developmental issues caused by gain-of-function variants in KCNH1.

bioRxiv · Nov 9, 2026 · PreprintNeuroscience

Machine Learning Resolves Functional Phenotypes and Therapeutic Responses in KCNQ2 Developmental Epileptic Encephalopathy iPSC Models

Dina Simkin, Syed M.A. Wafa, Mennat Gharib, Kelly A. Marshall, Yezi Yang, Linda C. Laux, Alfred L. George, Evangelos Kiskinis

The paper uses machine learning to analyze iPSC-derived neurons from KCNQ2-DEE patients, identifying functional phenotypes and showing retigabine's variable efficacy in rescuing disease features.

bioRxiv · Jul 26, 2025 · PreprintNeuroscience

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yizhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, María Dolores Martin‐de‐Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Mark S. LeDoux, Jennifer A. Kearney, , Peter Penzes

This study identifies PRRT2 as a key hub in an epilepsy network disrupted by 16p11.2 duplication and shows its correction rescues multiple neuropsychiatric and seizure-related phenotypes in mice.

Nature Communications · Feb 17, 2023Peer-reviewedNeuroscience

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

Dina Simkin, Timothy J. Searl, Brandon N Piyevsky, Marc P. Forrest, Luis A. Williams, Vaibhav Joshi, Hongkang Zhang, Steven J. Ryan, Michael Schwake, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Owen B. McManus, Graham T. Dempsey, J Gordon Millichap, , Evangelos Kiskinis

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.

bioRxiv · Sep 22, 2020 · PreprintNeuroscience