In vivo discovery of blood-brain barrier opening small molecules with FishNAP
Thomas Potts, Erin E McDonnell, Jacklyn Levey, L. Gall, Evangeline Coffinas, Colleen G Rutley, Neha Gururaj, Alexandra K Vindigni, Advait R Iyer, Kaitlyn A Pericone, Manan H Gosai, Megan E Canace, Natasha M. O’Brown
This study identifies small molecules that temporarily open the blood-brain barrier in zebrafish and mice, with reversible effects and potential for drug delivery.
bioRxiv · Sep 4, 2026 · PreprintNeuroscience