Natasha M. O’Brown

This study identifies small molecules that temporarily open the blood-brain barrier in zebrafish and mice, with reversible effects and potential for drug delivery.

The paper uses single-cell RNA sequencing to analyze inner ear development in zebrafish, identifying cell states and genes involved in sensory patches, semicircular canals, and endolymphatic sac formation.

This study shows that astrocytic RIPK3 reduces inflammation in viral encephalitis by increasing serpin protease inhibitors, improving survival and BBB integrity.

This study shows that IQGAP2 regulates immune cell entry into the CNS by modulating BBB function through adhesion receptors and antigen-processing machinery.

This study examines glial-vascular interactions in zebrafish brains across development, showing increasing glial coverage over time, with lower adult coverage compared to mammals.

The paper identifies Spock1 as a neuronal signal that regulates blood-brain barrier permeability by altering extracellular matrix and vascular gene expression in zebrafish and mice.

The paper studies zebrafish blood-brain barrier development, finding that suppression of transcytosis is critical for BBB formation and that Mfsd2a plays a conserved role in this process.