Jacklyn Levey

In vivo discovery of blood-brain barrier opening small molecules with FishNAP

This study identifies small molecules that temporarily open the blood-brain barrier in zebrafish and mice, with reversible effects and potential for drug delivery.

The Calcium Pump ATP2B1/PMCA1 Regulates CNS Vascular Development by Facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling

This study identifies ATP2B1 as a regulator of Norrin- and WNT7A/B-induced Frizzled4 signaling in endothelial cells, showing its role in CNS vascular development.

A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling

This study shows that an FZD4/LRP5 agonist improves pericyte coverage and vascular integrity by enhancing PDGFB signaling in a mouse model of pericyte deficiency.

C1q limits cystoid edema by maintaining basal beta-catenin-dependent signaling and blood-retina barrier function

This study shows that C1QA maintains blood-retina barrier function and limits cystoid edema by supporting beta-catenin-dependent signaling in a mouse model of retinal disease.

GeneWeld: a method for efficient targeted integration directed by short homology

GeneWeld enables efficient and precise targeted integration in multiple species using CRISPR/Cas9 with minimal homology arms.