Inactivation of a protein hydroxylase complex impairs replication fork restart in cancer and neurodevelopmental disorders
Tristan J. Kennedy, Sally C. Fletcher, Uncaar Boora, Erin Fraser-Williams, Arashpreet Kaur, Gareth W. Hughes, Eline Hendrix, Joanna R. Morris, Stephen J. Smerdon, Mathew L. Coleman
This study investigates how JMJD5 mutations affect replication fork restart and genome stability in cancer and neurodevelopmental disorders.
bioRxiv · Nov 22, 2025 · PreprintCancer Biology