Gareth W. Hughes

This study investigates how JMJD5 mutations affect replication fork restart and genome stability in cancer and neurodevelopmental disorders.

This paper characterizes TipA and TipB, two proteins from Bdellovibrio bacteriovorus, showing TipA's lipid-binding structure and TipB's role in inducing conformational changes in TipA.

This study identifies MlaFEDB as a flippase that uses ATP hydrolysis to transport phospholipids between membrane leaflets and shows ATP-independent phospholipid loading into MlaC.

The paper solves the crystal structure of MlaC and shows the Mla pathway exports phospholipids from the inner membrane to the periplasm, challenging the previous belief in retrograde transport.