Spreading alpha-Synuclein Oligomers Trigger Astrocyte Changes and Astrocyte-Glutamatergic Neuron system dysfunction in an Age-related Manner
Jaehyun LeeBae, Verena Bopp, Alicia Goreth, Veselin Grozdanov, Julia K. Kühlwein, Ermanno Gazzola, Daniel Rombach, Laura Meier, Leda Dimou, Karin M. Danzer
The paper investigates how alpha-synuclein oligomers spread in a mouse model of Parkinson's disease, identifying age-related astrocyte changes and dysfunction in the astrocyte-glutamatergic neuron system.
bioRxiv · Aug 8, 2025 · PreprintNeuroscience