Author

Jaehyun LeeBae

German Center for Neurodegenerative DiseasesORCID 0009-0002-1983-0074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:snRNA-seq· 2 Research Focus:clustering· 1

Frequent Co-Authors

Julia K. Kühlwein· 3 shared Karin M. DanzeriD· 3 shared Verena BoppiD· 3 shared Veselin GrozdanoviD· 3 shared Benjamin MayeriD· 2 shared Hartmut GeigeriD· 2 shared Martin Kiechle· 2 shared Alicia GorethiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Julia K. Kühlwein

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Targeting CDC42 with CASIN Reprograms Cell-Type-Specific Transcriptomes and MAPK-Driven Transcription Factor Networks in the Aging Brain

Jaehyun LeeBae, Verena Bopp, Bettina Moehrle, Julia K. Kühlwein, Veselin Grozdanov, Martin Kiechle, Benjamin Mayer, Hartmut Geiger, Karin M. Danzer

The paper shows that CASIN inhibits CDC42, reversing PD-related transcriptional changes and affecting MAPK and PI3K/AKT pathways in an aging mouse model.

bioRxiv · Aug 14, 2026 · PreprintNeuroscience

Molecular aging is the main driver of Parkinson's Disease

Verena Bopp, Jaehyun LeeBae, Patrick Oeckl, Julia K. Kühlwein, Veselin Grozdanov, Martin Kiechle, Benjamin Mayer, Bettina Möhrle, Hartmut Geiger, Karin M. Danzer

This study shows that aging processes drive Parkinson's Disease in a mouse model, independent of alpha-synuclein oligomers, by targeting CDC42 activity.

bioRxiv · Aug 27, 2025 · PreprintNeuroscience

Spreading alpha-Synuclein Oligomers Trigger Astrocyte Changes and Astrocyte-Glutamatergic Neuron system dysfunction in an Age-related Manner

Jaehyun LeeBae, Verena Bopp, Alicia Goreth, Veselin Grozdanov, Julia K. Kühlwein, Ermanno Gazzola, Daniel Rombach, Laura Meier, Leda Dimou, Karin M. Danzer

The paper investigates how alpha-synuclein oligomers spread in a mouse model of Parkinson's disease, identifying age-related astrocyte changes and dysfunction in the astrocyte-glutamatergic neuron system.

bioRxiv · Aug 8, 2025 · PreprintNeuroscience