Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liver
Yuzhi Huang, Ting Li, Erwei Hu, Peiyao Zhang, Xueying Feng, Heze Fan, Zihao Wang, Yuyang Lei, Chen Wang, Wenbo Yang, Lijun Wang, Peining Liu, Bin Du, Yan Wu, Wenbo Li, , Juan Zhou
This study identifies miR-148a-3p as a key mediator of CKD-induced hyperlipidemia and atherosclerosis by targeting SIK1/AMPK1 in the liver via exosomal transfer.
bioRxiv · Oct 8, 2025 · PreprintPathology