John Y.-J. Shyy

This study shows that obesity increases atherosclerosis through an inter-tissue miR-30e-SLC7A11 axis, where adipose-derived miR-30e-5p targets SLC7A11 in vascular endothelial cells, leading to metabolic and functional impairments.

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

This study identifies MRG15 as a mechanosensitive suppressor of atherosclerosis by showing its role in regulating endothelial inflammation and adhesion pathways under disturbed flow.

This study shows that ACE2 phosphorylation at Ser-680 modulates angiogenesis by affecting AP-1 activation in vascular endothelial cells.

This study identifies miR-148a-3p as a key mediator of CKD-induced hyperlipidemia and atherosclerosis by targeting SIK1/AMPK1 in the liver via exosomal transfer.

The paper identifies smooth muscle Cxcl12 activation as a contributor to vascular remodeling in flow-induced pulmonary hypertension using a new murine model.

This study shows that oxidative stress modifies miR-483 to 8OH-G miR-483, leading to endothelial dysfunction and increased atherosclerosis risk through altered targetomes.