Gli2 Overexpression Alters the Differentiation Status of Dedifferentiated Liposarcoma Cells and Results in an Immunosuppressive Myeloid Phenotype in Orthotopic Tumors
Natalie E. Bennett, Erik P. Beadle, Dominique Parker, Erykah J. Coe, Matthew A. Cottam, Jennifer E. Baum, Jade S. Miller, Joseph Serrenho, Julie A. Rhoades
This study shows that Gli2 overexpression in dedifferentiated liposarcoma cells reduces adipogenic differentiation, increases osteoblast markers, and promotes an immunosuppressive myeloid phenotype in tumors.
bioRxiv · Sep 18, 2024 · PreprintCancer Biology