A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis
Ezzat Hashemi, Isha N. Srivastava, Alejandro Aguirre, Ezra Yoseph, Esha Kaushal, Avni Awani, Jae Kyu Ryu, Katerina Akassoglou, Shahrzad Talebian, Pauline Chu, Laura Jean Pisani, Patricia Leonor Musolino, Lawrence Steinman, Kristian P. Doyle, William H. Robinson, , Keith P. van Haren
This paper develops a novel mouse model of cerebral adrenoleukodystrophy (cALD) that replicates human disease features and highlights NLRP3 inflammasome activation in lesion pathogenesis.
Annals of Neurology · Oct 28, 2024Peer-reviewedNeuroscience