Kristian P. Doyle

This study shows that low-dose ketamine protects against Parkinson's-like motor deficits in rats without relying on BDNF-TrkB signaling.

This study shows that stroke increases hippocampal neurogenesis but leads to maladaptive morphological features in newborn neurons across multiple mouse stroke models.

This study evaluates cognitive outcomes after stroke in mice using multiple models and tests, finding inconsistent results and highlighting challenges in pre-clinical stroke cognition research.

This study identifies a sex-specific reactivation of developmental pruning processes as a cause of cognitive dysfunction after brain trauma and shows the pathway is reversible.

This study shows that manual lymph drainage massage of the head and neck improves cognition and reduces Aβ and NfL levels in 5x-FAD mice.

This paper develops a novel mouse model of cerebral adrenoleukodystrophy (cALD) that replicates human disease features and highlights NLRP3 inflammasome activation in lesion pathogenesis.

This study shows that LM11A-31, a p75NTR modulator, improves stroke recovery by enhancing brain metabolism, neurotransmitter levels, and reducing neurodegeneration in mice.

This study shows that repeated HPβCD treatment reduces chronic inflammation and cognitive decline after stroke by modulating lipid metabolism and immune responses.

This paper compares ischemic inflammation in the heart and brain, finding a second inflammatory wave in the brain post-stroke linked to cholesterol crystals and osteopontin, which drives secondary neurodegeneration.