Author

Ezzat Hashemi

Stanford MedicineORCID 0000-0003-0868-4331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Isha N. SrivastavaiD· 2 shared Joshua L. BonkowskyiD· 2 shared Keith P. van HareniD· 2 shared Troy C. LundiD· 2 shared Alejandro Aguirre· 1 shared Ali S. FatemiiD· 1 shared Allan Meldgaard LundiD· 1 shared Avni Awani· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Isha N. SrivastavaORCID

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2 papers

Recent·Most cited

Disease Outcomes in Boys with ABCD1 Variants Identified by Newborn Screening for X-ALD

Cecilie S. Videbæk, Danielle H.J. Kim, Hannah S. Hart, Robert E. Thompson, Razina Aziz‐Bose, Lachelle Purnell-Savoy, Sonum Bharill, Ezzat Hashemi, Joseph Orsini, Elisa Seeger, Miranda McAuliffe, Isha N. Srivastava, Jennifer MacLean, Sejal Shah, Ali S. Fatemi, , Keith P. van Haren

The paper evaluates disease outcomes in boys with ABCD1 variants detected via newborn screening for ALD, finding that VUS variants are associated with lower rates of adrenal insufficiency and lower C26:0-LPC levels compared to pathogenic variants.

medRxiv · Jul 2, 2026 · PreprintGenetic & Genomic Medicine

A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis

Ezzat Hashemi, Isha N. Srivastava, Alejandro Aguirre, Ezra Yoseph, Esha Kaushal, Avni Awani, Jae Kyu Ryu, Katerina Akassoglou, Shahrzad Talebian, Pauline Chu, Laura Jean Pisani, Patricia Leonor Musolino, Lawrence Steinman, Kristian P. Doyle, William H. Robinson, , Keith P. van Haren

This paper develops a novel mouse model of cerebral adrenoleukodystrophy (cALD) that replicates human disease features and highlights NLRP3 inflammasome activation in lesion pathogenesis.

Annals of Neurology · Oct 28, 2024Peer-reviewedNeuroscience