Author

Esmay C. van der Toorn

Erasmus MC

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alex MaasiD· 1 shared Fréderike W. RiemslaghiD· 1 shared Laurens W. J. BosmaniD· 1 shared Renate K. HukemaiD· 1 shared Rob F. M. VerhageniD· 1 shared Rob WillemseniD· 1 shared

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2021-2021 · peak 1/yr

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1 shared paperNeuroscience

Alex MaasORCID

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1 paper

Recent·Most cited

NeuroscienceDisease Models & MechanismsPeer-reviewedJan 11, 2021

Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

Fréderike W. Riemslagh, Esmay C. van der Toorn, Rob F. M. Verhagen…·Rob Willemsen

This paper introduces a new inducible mouse model expressing C9ORF72 G4C2 repeats that causes RAN translation and muscular atrophy, showing that early intervention can prevent but not reverse the phenotype.

17 citations

mouseexperimental assay

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