Author

Renate K. Hukema

Erasmus MCORCID 0000-0002-1580-4154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex MaasiD· 1 shared Allison Loaiza Zambrano· 1 shared Benedetta BolognesiiD· 1 shared Benjamin LangiD· 1 shared Ellen GelpíiD· 1 shared Emre KuliD· 1 shared Esmay C. van der Toorn· 1 shared Fernando Cid-SamperiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Alex MaasORCID

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3 papers

Recent·Most cited

Modelling Fragile X-Associated Neuropsychiatric Disorders in Young Inducible 90CGG Premutation Mice

Gürsel Çalışkan, Sara Enrile Lacalle, Emre Kul, Miguel del Ángel, Allison Loaiza Zambrano, Renate K. Hukema, Mónica Santos, Oliver Stork

This study uses a doxycycline-inducible 90CGG mouse model to show that FXAND features progress from hyperactivity to anxiety to motor dysfunction, with reversible electrophysiological and proteomic changes.

Brain · May 30, 2025Peer-reviewedNeuroscience

Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

Fréderike W. Riemslagh, Esmay C. van der Toorn, Rob F. M. Verhagen, Alex Maas, Laurens W. J. Bosman, Renate K. Hukema, Rob Willemsen

This paper introduces a new inducible mouse model expressing C9ORF72 G4C2 repeats that causes RAN translation and muscular atrophy, showing that early intervention can prevent but not reverse the phenotype.

Disease Models & Mechanisms · Jan 11, 2021Peer-reviewedNeuroscience

An integrative study on ribonucleoprotein condensates identifies scaffolding RNAs and reveals a new player in Fragile X-associated Tremor/Ataxia Syndrome

Fernando Cid-Samper, Mariona Gelabert‐Baldrich, Benjamin Lang, Nieves Lorenzo-Gotor, Riccardo Delli Ponti, Lies-Anne W. F. M. Severijnen, Benedetta Bolognesi, Ellen Gelpí, Renate K. Hukema, Teresa Botta‐Orfila, Gian Gaetano Tartaglia

The paper identifies scaffolding RNAs and a new player, TRA2A, in Fragile X-associated Tremor/Ataxia Syndrome by studying RNA-RBP interactions and their aggregation.

bioRxiv · Nov 12, 2018 · PreprintMolecular Biology