Laurens W. J. Bosman

The paper investigates the electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive and finds they exhibit distinct firing patterns and response characteristics compared to non-projecting neurons.

This study shows that ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance in a mouse model of SCA2.

This study investigates how cerebellar Purkinje cells control tongue movements during drinking, showing that complex spikes signal target position changes and simple spikes influence movement direction.

The paper introduces a novel behavioral test, MEGIT, to assess social preference in mice and shows it detects differences in social behavior in genetic models of ASD and WBS.

This study shows that different Purkinje cell pathologies in mice lead to distinct patterns of progressive gait ataxia, highlighting the importance of pathological mechanisms in disease progression.

This paper develops a long-deletion mouse model of Williams syndrome to study vascular and neural phenotypes, finding that Ncf1 modulates both cardiovascular and neuropsychological symptoms.

The paper investigates how climbing fiber activity in the cerebellum adapts to the saliency of sensory inputs and correlates with action readiness in mice during a go/no-go task.

This paper introduces a new inducible mouse model expressing C9ORF72 G4C2 repeats that causes RAN translation and muscular atrophy, showing that early intervention can prevent but not reverse the phenotype.

This study shows cerebellar Purkinje cells modulate S1-M1 coherence in theta and gamma bands during whisker stimulation, with effects dependent on region and behavior.

This study investigates how Purkinje cell activity in the cerebellum coordinates autonomic and sensorimotor behaviors during respiration, showing context- and phase-dependent effects.

This study investigates how subthreshold oscillations and synaptic inputs shape complex spike timing in the inferior olive of awake mice, revealing semi-periodic activity patterns and resonance properties.

The paper investigates how inferior olive neurons respond to different sensory inputs and shows their firing is influenced by recent activity history rather than stimulus strength.

This study shows that increased simple spike activity in Purkinje cells, facilitated by long-term potentiation at parallel fiber synapses, contributes to whisker reflex adaptation in mice.

This paper describes a novel SCA2 mouse model with CAG100 expansion in Atxn2, showing reduced lifespan and vestibulo-cerebellar dysfunction due to axon-myelin disconnection.