KDM5B expression is suppressed by MYC in a negative feedback loop to promote cell survival.
Tilottama Chatterjee, Ethan Beffert, Gabrielle S. Dewson, Delaney K. Sullivan, Benedict Anchang, Rosalie C. Sears, Daniel F. Liefwalker
The paper identifies a negative feedback loop where MYC suppresses KDM5B, leading to increased cell survival and tumor progression.
bioRxiv · Apr 12, 2025 · PreprintCancer Biology