Cellular rules underlying psychedelic control of prefrontal pyramidal neurons
Tyler G. Ekins, Isla A. W. Brooks, Sameer Kailasa, Chloe Rybicki-Kler, Izabela Jedrasiak‐Cape, Ethan Donoho, George A. Mashour, Jason C. Rech, Omar J. Ahmed
This study shows that psychedelics suppress intrinsic excitability of prefrontal pyramidal neurons via M-current channels, independent of 5-HT2AR activation, and reduces working memory timespan.
bioRxiv · Oct 20, 2023 · PreprintNeuroscience