George A. Mashour

This study identifies four wave propagation motifs in the human brain across different states of consciousness and shows how they reconfigure in diminished and psychedelic states.

The paper examines integration-segregation patterns in brain networks across psychedelic and sedated states using functional MRI, finding opposing configurations in these states.

This study investigates the neurochemical and neurophysiological effects of DMT in rats, finding dose-dependent increases in serotonin and dopamine and changes in EEG power and functional connectivity.

This study uses low-intensity focused ultrasound to modulate thalamic regions and shows how they affect visual perception and object recognition.

This study investigates how five psychedelic drugs affect local brain synchrony and global functional connectivity using fMRI, finding disrupted local synchrony and enhanced global connectivity across all drugs.

This study shows that proximity to explosive synchronization determines criticality loss and recovery in neural and economic systems, with implications for network resilience.

This study introduces Relative Phase Analysis to reveal sub-second switches between top-down and bottom-up brain modes, showing distinct dynamics in consciousness and ADHD.

This study shows that DOI, a serotonergic psychedelic, can reverse general anesthesia and restore brain dynamics in rats, as evidenced by behavioral arousal and recovery of functional connectivity.

The paper introduces an fMRI-based measure of integration-segregation balance to differentiate conscious and unconscious brain states, finding significant shifts during anesthesia and sleep.

The paper uses fMRI to compare neural connectivity in psychedelic, sleep, and sedated states, finding global connectivity increases in psychedelics and decreases in sleep/sedation, supporting global theories of consciousness.

This study investigates the role of preoptic glutamatergic neurons in REM sleep regulation, finding they suppress REMs and disrupt sleep homeostasis when activated.

This study examines how propofol affects thalamic core-matrix architecture using fMRI in humans, finding a shift toward unimodal geometry during unconsciousness.

This study examines how psilocybin affects brain network organization in rats, finding dose-dependent changes in connectivity and phase-amplitude coupling.

This study shows nitrous oxide reduces functional differentiation in brain networks and correlates with psychedelic experiences.

This study shows that psychedelics suppress intrinsic excitability of prefrontal pyramidal neurons via M-current channels, independent of 5-HT2AR activation, and reduces working memory timespan.

This study shows that a single intravenous dose of psilocybin reduces mechanical hypersensitivity in a rat model of chronic pain for 28 days but has limited effect on thermal hyperalgesia.

This study shows that both canonical and non-canonical psychedelics induce similar changes in brain network connectivity in humans.

This study compares electroencephalographic signatures of urethane anesthesia and natural sleep-wake states in rats, finding distinct neurophysiological features in urethane that differentiate it from sleep.

This study shows that brain network criticality enables switching between internal and external processing modes, with distinct network configurations favoring each mode in conscious states.

This study investigates recovery of consciousness and cognition after general anesthesia in humans, finding that executive function recovers before other cognitive domains and frontal cortical activity recovers faster than posterior.

This study investigates the neural correlates of the shamanic state of consciousness using EEG in practitioners and controls, finding distinct brain activity patterns compared to psychedelic-induced states.

This study examines changes in brain network motifs during loss and recovery of consciousness using EEG data from healthy subjects under anesthesia.

The paper shows that postrhinal theta oscillations have differential encoding of running speed through amplitude and waveform shape, with distinct behavioral correlates.

This study investigates how network criticality influences integrated information (Phi) in human brain networks using simulations and EEG data during different consciousness states.

The paper shows that cholinergic stimulation of the prefrontal cortex restores wakefulness in anesthetized rats, while noradrenergic stimulation does not.