An Integrated Preclinical Platform for Lethal Neuroendocrine Prostate Cancer from Rapid Autopsy Bone and Liver Metastases.
Borum Ryu, Thomas C. Caffrey, Sriya Sridhar, Catherine S. Johnson, Ramia J. Salloom, Kabhilan Mohan, Grace Waldron, Amanda Robotham, Ethan M Wilcox, Diane L. Costanzo-Garvey, Janice Taylor, James Talaska, Rachel Rhatigan, Quan P. Ly, Heather C. Jensen-Smith, , Grinu Mathew
This paper establishes patient-derived models of neuroendocrine prostate cancer (NEPC) from metastases, showing they retain tumor heterogeneity and can model metastatic progression.
bioRxiv · Jul 23, 2026 · PreprintCancer Biology