Thomas C. Caffrey

This paper establishes patient-derived models of neuroendocrine prostate cancer (NEPC) from metastases, showing they retain tumor heterogeneity and can model metastatic progression.

This study uses AI-driven proteomics to identify molecular transitions in pancreatic cancer precursors, revealing early molecular changes in histologically normal tissue.

This study identifies an iron-regulated signaling pathway involving MSRA and PKA that drives adipose browning and cancer cachexia, showing that MsrA deletion reduces cachexia in PDA models.