The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation
Stefan Reber, Daniel Jutzi, Helen A. Lindsay, Anny Devoy, Jonas Mechtersheimer, Brunno Rocha Levone, Michal Domanski, Eva Bentmann, Dorothee Dormann, Oliver Mühlemann, Silvia M.L. Barabino, Marc‐David Ruepp
The paper develops a method to purify phase-separated FUS droplets and shows that LLPS alters FUS interactome composition, linking it to chromatin remodeling and mitochondrial function in ALS.
Nucleic Acids Research · Jun 28, 2021Peer-reviewedMolecular Biology