Silvia M.L. Barabino

This study shows that inhibiting PGM3 in pancreatic cancer cells disrupts DNA repair pathways, induces a BRCAness-like state, and increases sensitivity to PARP inhibitors and radiation.

This study shows that nuclear DNA damage directly causes mitochondrial dysfunction in C9ORF72 ALS/FTD by triggering a DNA damage response that depletes NAD+ and impairs mitochondrial bioenergetics.

The paper develops a method to purify phase-separated FUS droplets and shows that LLPS alters FUS interactome composition, linking it to chromatin remodeling and mitochondrial function in ALS.

This study shows that FUS-dependent liquid-liquid phase separation is essential for early DNA damage response activation and repair complex assembly.