Author

Stefan Reber

King's College LondonORCID 0000-0002-4885-3550Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:protein sequence· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Marc‐David RueppiD· 4 shared Jonas MechtersheimeriD· 3 shared Brunno Rocha LevoneiD· 2 shared Oliver MühlemanniD· 2 shared Silvia M.L. BarabinoiD· 2 shared Alexander W. RappiD· 1 shared Andreas MaiseriD· 1 shared Anny DevoyiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersNeuroscience

Marc‐David RueppORCID

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Author profile →

4 papers

Recent·Most cited

A validated panel of commercial antibodies for reliable detection of FET proteins.

Sara Tacconelli, Laura Odemwingie, Stefan Reber, Sergio Di Pancrazio, Tatjana I. Zoller, Luca Biasetti, Claire Troakes, Marc‐David Ruepp, Caroline A. Vance

The paper evaluates 23 commercial antibodies for detecting FET proteins, identifies specific ones, and provides a validated panel for reliable research.

bioRxiv · Nov 19, 2025 · PreprintNeuroscience

Single-cell RNA sequencing across isogenic FUS and TARDBP ALS lines reveals a shared early mitochondrial dysfunction unique to motor neurons.

Christoph Schweingruber, Jik Nijssen, Jonas Mechtersheimer, Stefan Reber, Mélanie Lebœuf, Niamh Louise O’Brien, Irene Mei, Erin C. Hedges, Michaela Keuper, Julio Aguila Benitez, Vlad Radoi, Martin Jastroch, Marc‐David Ruepp, Eva Hedlund

This study uses single-cell RNA sequencing to identify shared mitochondrial dysfunction in motor neurons across FUS and TARDBP ALS mutations, suggesting common toxic mechanisms.

Nature Communications · May 19, 2025Peer-reviewedNeuroscience

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation

Stefan Reber, Daniel Jutzi, Helen A. Lindsay, Anny Devoy, Jonas Mechtersheimer, Brunno Rocha Levone, Michal Domanski, Eva Bentmann, Dorothee Dormann, Oliver Mühlemann, Silvia M.L. Barabino, Marc‐David Ruepp

The paper develops a method to purify phase-separated FUS droplets and shows that LLPS alters FUS interactome composition, linking it to chromatin remodeling and mitochondrial function in ALS.

Nucleic Acids Research · Jun 28, 2021Peer-reviewedMolecular Biology

FUS-dependent liquid-liquid phase separation is an early event in double-strand break repair

Brunno Rocha Levone, Silvia Carolina Lenzken, Marco Antonaci, Andreas Maiser, Alexander W. Rapp, Francesca Conte, Stefan Reber, Jonas Mechtersheimer, Antonella Ellena Ronchi, Oliver Mühlemann, Heinrich Leonhardt, M. Cristina Cardoso, Marc‐David Ruepp, Silvia M.L. Barabino

This study shows that FUS-dependent liquid-liquid phase separation is essential for early DNA damage response activation and repair complex assembly.

The Journal of Cell Biology · Feb 5, 2021Peer-reviewedMolecular Biology