NET1/ARHGEF8 is a mechanosensitive Guanine Exchange Factor controlling vascular smooth muscle cells' contractility
Mary-Adel Mrad, Surya Prakash Rao Batta, Virginie Vignard, Marc Rio, Gilliane Chadeuf, Eva Gros, Vincent Sauzeau, Gervaise Loirand, Anne-Clémence Vion
This study identifies NET1/ARHGEF8 as a mechanosensitive RhoGEF that regulates vascular smooth muscle cell contractility and adhesion in response to cyclic stretch.
bioRxiv · Nov 26, 2025 · PreprintCell Biology