β-cell dedifferentiation is associated with epithelial-mesenchymal transition triggered by miR-7-mediated repression of mSwi/Snf complex
Tracy C S Mak, Yorrick von Ohlen, Yi Fang Wang, Eva Kane, Kaste Jurgaityte, Pedro Ervilha, PAULINE L. CHABOSSEAU, Walter Distaso, Victoria Salem, Alejandra Tomás, Markus Stoffel, Piero Marchetti, Andrew M. James Shapiro, Guy A. Rutter, Mathieu Latreille
This study identifies miR-7-mediated repression of Brg1 as a driver of β-cell dedifferentiation through EMT, leading to fibrosis and impaired glucose tolerance in diabetes.
bioRxiv · Oct 1, 2019 · PreprintGenomics