Author

Kaste Jurgaityte

Hammersmith HospitalORCID 0009-0004-4356-6677Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Abhay KotechaiD· 1 shared Adrian F. Koh· 1 shared Alejandra TomásiD· 1 shared Andrew M. James ShapiroiD· 1 shared Ash K. BahliD· 1 shared Basil J. GreberiD· 1 shared Eva Kane· 1 shared Guy A. RutteriD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Abhay KotechaORCID

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2 papers

Recent·Most cited

High-resolution cryo-electron microscopy of the human CDK-activating kinase for structure-based drug design

Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste Jurgaityte, Ash K. Bahl, Simak Ali, Abhay Kotecha, Basil J. Greber

The paper determines high-resolution structures of CDK-activating kinase using cryo-EM, revealing inhibitor interactions and providing a framework for structure-based drug design.

bioRxiv · Apr 7, 2023 · PreprintMolecular Biology

β-cell dedifferentiation is associated with epithelial-mesenchymal transition triggered by miR-7-mediated repression of mSwi/Snf complex

Tracy C S Mak, Yorrick von Ohlen, Yi Fang Wang, Eva Kane, Kaste Jurgaityte, Pedro Ervilha, PAULINE L. CHABOSSEAU, Walter Distaso, Victoria Salem, Alejandra Tomás, Markus Stoffel, Piero Marchetti, Andrew M. James Shapiro, Guy A. Rutter, Mathieu Latreille

This study identifies miR-7-mediated repression of Brg1 as a driver of β-cell dedifferentiation through EMT, leading to fibrosis and impaired glucose tolerance in diabetes.

bioRxiv · Oct 1, 2019 · PreprintGenomics