Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs
Hayden Roys, Assyl Arykbayeva, Sarah K. Friedman, Gabriel Gifford, Eva R. Palmer, Alex Rogers, Emily N. H. Tran, L. G. Fry, Alexx Weaver, Anne Kidd Bowlin, Meghan D. Jones, Michael R. Eledge, Karl W. Boehme, Gregory R. Naumiec, Tiffany Weinkopff
The paper synthesizes and evaluates 24 disquaramide compounds against Leishmania major, finding six significantly reduce parasite numbers without host toxicity.
bioRxiv · Aug 23, 2024 · PreprintMicrobiology