L. G. Fry

This study shows that GBPs balance iNOS and ARG-1 in myeloid cells to control Leishmania major infection, with GBPChr3 knockout mice showing increased parasite load and disease severity.

This study shows impaired lymphatic function contributes to non-healing cutaneous leishmaniasis caused by L. amazonensis and demonstrates that targeting lymphatics can reduce inflammation.

This study identifies increased translational activity and immune activation in lymphatic endothelial cells during cutaneous leishmaniasis.

This study shows that host inflammatory responses, not the parasite, drive HIF-α signaling in macrophages during Leishmania major infection, leading to HIF-α-dependent suppression of protein translation in a pro-inflammatory environment.

The paper synthesizes and evaluates 24 disquaramide compounds against Leishmania major, finding six significantly reduce parasite numbers without host toxicity.