Hayden Roys

Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells

This study shows that GBPs balance iNOS and ARG-1 in myeloid cells to control Leishmania major infection, with GBPChr3 knockout mice showing increased parasite load and disease severity.

Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis

This study shows impaired lymphatic function contributes to non-healing cutaneous leishmaniasis caused by L. amazonensis and demonstrates that targeting lymphatics can reduce inflammation.

Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis

This study identifies increased translational activity and immune activation in lymphatic endothelial cells during cutaneous leishmaniasis.

HIF-alpha signaling mediates the macrophage inflammatory response during Leishmania major infection

This study shows that host inflammatory responses, not the parasite, drive HIF-α signaling in macrophages during Leishmania major infection, leading to HIF-α-dependent suppression of protein translation in a pro-inflammatory environment.

Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs

The paper synthesizes and evaluates 24 disquaramide compounds against Leishmania major, finding six significantly reduce parasite numbers without host toxicity.