Early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A developmental and epileptic encephalopathy
Yana Reva, Katharina Ulrich, Xian Xin, Yuanyuan Liu, Michaela Barboni, Daniil Kirianov, Nima Mojtahedi, Sarah Schoeb, Hanna Oelßner, Daria Savitska, Mohamad Samehni, Francesca Xompero, Eva Schulze, Heinz Beck, Fabio Morellini, , Dirk Isbrandt
This study shows that early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A-DEE, suggesting it as a therapeutic target.
bioRxiv · Jun 29, 2025 · PreprintNeuroscience