Heinz Beck

The paper shows that CA3 axons maintain a stable spatial coding manifold that encodes aversive information without disrupting spatial representation.

This study evaluates photopharmacology agents in human and mouse brain tissue to control epilepsy, finding that caged propofol suppresses epileptiform activity across species.

The paper shows that dendrites have nanoscale constrictions that create electrical compartments, altering synaptic integration in neurons.

This study shows that early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A-DEE, suggesting it as a therapeutic target.

This study identifies region-specific spreading depolarization as a key factor in post-ictal behavioral abnormalities in epilepsy using mouse and human data.

The paper reports that common AAV transduction procedures can induce artefactual Ca2+ micro-waves in the hippocampus and provides an alternative method to avoid this issue.

The paper shows that astrocytic signaling via endocannabinoid receptors modulates dendritic integration in hippocampal pyramidal cells, enhancing spatial learning through frequency-dependent feedback.

The paper identifies a Na+ channel-dependent mechanism in hippocampal dendrites that contributes to spatial memory deficits in epilepsy and shows that targeting Nav1.3 channels can reverse these deficits.

The paper investigates how microglia change their phenotype in acute brain slices and how these changes affect neuronal network activity.

This paper introduces a method to simultaneously measure excitatory and inhibitory conductances in neurons using current clamp recordings and sinusoidal current injection.

This study identifies SLK as critical for dendritic complexity and inhibitory synapse maintenance in neurons, with implications for human cortical malformations.

The paper shows that dentate gyrus activity during immobility generates structured population patterns that are necessary for forming spatial memories.

This paper introduces a novel mouse model of focal cortical seizures using chemogenetic inhibition of GABAergic neurons, showing reliable induction of seizures with characteristics similar to human epilepsy.

The paper shows that unspecific expression in Cre-driver lines can lead to large functional effects, using SST-Cre mice to demonstrate excitatory current in non-target cells.

The paper quantifies how feedback inhibition in the mouse dentate gyrus contributes to frequency-dependent pattern separation of temporally structured inputs.