Dirk Isbrandt

This study shows that mitochondrial turnover at GABAergic synapses affects seizure vulnerability, with gene therapy reversing the effects.

This study shows that early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A-DEE, suggesting it as a therapeutic target.

This study presents two genetic mouse models of HCN1 epileptic encephalopathy, showing seizure susceptibility and adverse drug responses, highlighting the need for tailored therapies.

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

This study shows that HCN-channel dysfunction in neural progenitors causes microcephaly by disrupting cell cycle progression and proliferation in mice.

This study shows that NKCC1 deletion in developing mice has minimal impact on hippocampal network development and behavior, challenging its essential role in these processes.