Pruning and thresholding approach for methylation risk scores in multi-ancestry populations
Junyu Chen, Evan Gatev, Todd M. Everson, Karen N. Conneely, Nastassja Koen, Michael P. Epstein, Michael Steffen Kobor, Heather Joy Zar, Dan Joseph Stein, Anke Hüls
The paper introduces a pruning and thresholding method for methylation risk scores to improve prediction across multi-ancestry populations, showing better performance than simple thresholding.
Epigenetics · Mar 12, 2023Peer-reviewedGenetic & Genomic Medicine