This paper introduces h-ARF, a high-dimensional extension of adversarial random forests for generating synthetic omics data, showing improved performance in preserving feature distributions and downstream tasks.

bioRxiv · Sep 15, 2026 · PreprintBioinformatics

Multi-tissue transcriptome-wide association study identifies 29 risk genes associated with attention-deficit/hyperactivity disorder

Sarina Abrishamcar, Qile Dai, Jingjing Yang, Anke Hüls, Michael P. Epstein

This study uses a multi-tissue transcriptome-wide association study to identify 29 risk genes for ADHD, including six previously unlinked genes.

medRxiv · Feb 22, 2026 · PreprintGenetic & Genomic Medicine

Cell type-specific methylome-wide association studies of childhood ADHD symptoms

Mandy Meijer, Marieke Klein, Doretta Caramaschi, Shaunna L. Clark, Marta Cosín‐Tomás, Nastassja Koen, Xueling Lu, Rosa H. Mulder, Stefan W. Röder, Yining Zhang, Lea Zillich, Mariona Bustamente, Michael Deuschle, Janine F. Felix, Juan R. González, , Edwin J. C. G. van den Oord

This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

European Neuropsychopharmacology · Oct 26, 2025Peer-reviewedGenetic & Genomic Medicine

Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Alexander Neumann, Sara Sammallahti, Marta Cosín‐Tomás, Sarah E. Reese, Matthew J Suderman, Silvia Alemany, Catarina Almqvist, Sandra Andrušaitytė, Syed Hasan Arshad, Marian J. Bakermans‐Kranenburg, Lawrence Joseph Beilin, Carrie V. Breton, Mariona Bustamante, Darina Czamara, Dana Dabelea, , Charlotte A. M. Cecil

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

medRxiv · Feb 29, 2024 · PreprintGenetic & Genomic Medicine

Pruning and thresholding approach for methylation risk scores in multi-ancestry populations

Junyu Chen, Evan Gatev, Todd M. Everson, Karen N. Conneely, Nastassja Koen, Michael P. Epstein, Michael Steffen Kobor, Heather Joy Zar, Dan Joseph Stein, Anke Hüls

The paper introduces a pruning and thresholding method for methylation risk scores to improve prediction across multi-ancestry populations, showing better performance than simple thresholding.

Epigenetics · Mar 12, 2023Peer-reviewedGenetic & Genomic Medicine

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

Anke Hüls, Chloe Robins, Karen N. Conneely, Rachel D. Edgar, Philip L. De Jager, David Alan Bennett, Aliza P. Wingo, Michael P. Epstein, Thomas S. Wingo

The paper identifies DNA methylation in the CLDN5 locus as associated with cognitive decline, independent of neuropathology, suggesting a role for the blood-brain barrier in cognitive trajectory.

Biological Psychiatry · Feb 1, 2022Peer-reviewedGenetics

A healthy childhood environment helps to combat inherited susceptibility to obesity

Anke Hüls, Marvin N. Wright, Leonie Helen Bogl, Jaakko A. Kaprio, Lauren Lissner, Dénes Molnár, Luis Alberto Moreno, Stefaan De Henauw, Alfonso Siani, Toomas Veidebaum, Wolfgang Ahrens, Iris Pigeot, Ronja Foraita, on behalf of the IDEFICS/I.Family consortia

This study shows that a healthy childhood environment can reduce the risk of obesity in children with a genetic predisposition to the condition.

International Journal of Obesity · Mar 22, 2021Peer-reviewedGenetics

Association between DNA Methylation Levels in Brain Tissue and Late-Life Depression in Community-Based Participants

Anke Hüls, Chloe Robins, Karen N. Conneely, Philip L. De Jager, David Alan Bennett, Michael P. Epstein, Thomas S. Wingo, Aliza P. Wingo

This study identifies DNA methylation loci associated with late-life depression in brain tissue, highlighting sex-specific differences.

Translational Psychiatry · Jul 30, 2020Peer-reviewedGenetic & Genomic Medicine