Extracellular Vimentin is a Damage-Associated Molecular Pattern Protein Serving as an Agonist of TLR4 in Human Neutrophils
Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki
This study shows extracellular vimentin and its citrullinated form activate TLR4 on human neutrophils, influencing migration, NET formation, and pathogen phagocytosis differently.
Cell Communication and Signaling · Feb 5, 2025Peer-reviewedImmunology