Paul A. Janmey

Tissue-like compression stiffening in biopolymer networks induced by aggregated and irregularly shaped inclusions

This study shows that aggregated or irregularly shaped inclusions can induce compression stiffening in biopolymer networks at low volume fractions, mimicking tissue behavior.

Role of nuclear ATPases in nuclear mechanics and cell migration through confined spaces: opposite effects of BRG1 and cohesin

This study shows that BRG1 stiffens isolated nuclei and inhibits cell migration through tight spaces, while cohesin softens nuclei and enhances migration.

Intrahepatic crystals from elevated dietary cholesterol are sufficient to stiffen the liver

This study shows that elevated dietary cholesterol in rats leads to liver lipid crystals, which increase tissue stiffness and fibrosis progression in a model of MASLD.

Modeling tumor transport and growth with poroelastic biopolymer networks

This study models how poroelastic properties of the extracellular matrix affect tumor growth and transport through hydrogel experiments and computational simulations.

Plasma Gelsolin Prevents Organ-Specific Inflammation and Enhances Innate Immune Function in a Systemic Candida albicans Infection

This study shows that plasma gelsolin reduces inflammation and fungal burden in a mouse model of candidemia, enhancing innate immune function.

Tissue-dependent mechanosensing by cells derived from human tumors

The paper investigates how cells from different tissue types respond to changes in ECM mechanics and composition, finding significant heterogeneity and the role of HA in modulating cell mechanics.

Extracellular Vimentin is a Damage-Associated Molecular Pattern Protein Serving as an Agonist of TLR4 in Human Neutrophils

This study shows extracellular vimentin and its citrullinated form activate TLR4 on human neutrophils, influencing migration, NET formation, and pathogen phagocytosis differently.

Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1

This study shows that BRG1 activity fluidizes the nucleus, altering its stiffness and dissipating mechanical energy, with implications for nuclear mechanics and remodeling.

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation

This study identifies the Piezo-Atr-Chek1-Cdc25 pathway as an inhibitory mechanism for axon regeneration, showing that disrupting it enhances regeneration in Drosophila and mammals.

Loss of vimentin intermediate filaments decreases peri-nuclear stiffness and enhances cell motility through confined spaces