ATRX Deficiency Drives Aberrant Type I Interferon Signalling Through cGAS-Dependent Transcriptional Dysregulation
Marie‐Thérèse El‐Daher, Eve L. White, Andreas Fellas, Graeme R. Grimes, Simone Pelliciari, Ge Zhu, Tom A Tait, Carolina Uggenti, Natalie F. Blair, Erisa Nita, Philippe Emmanuel Gautier, Hywel Dunn-Davies, Sophie Glen, Somdutta Dhir, Mathieu Paul Rodero, , Yanick Joseph Crow
This study identifies ATRX deficiency as a driver of aberrant type I interferon signaling via cGAS-dependent transcriptional dysregulation in patients with cerebral white matter disease.
Nature Communications · Oct 8, 2026Peer-reviewedImmunology