Alice Lepelley

ATRX Deficiency Drives Aberrant Type I Interferon Signalling Through cGAS-Dependent Transcriptional Dysregulation

This study identifies ATRX deficiency as a driver of aberrant type I interferon signaling via cGAS-dependent transcriptional dysregulation in patients with cerebral white matter disease.

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates

This study shows NAP1 switches from enhancing to limiting TBK1 activity through condensate formation, affecting IFN induction and linking to interferonopathies.

Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling

This study shows that MTPAP loss causes mitochondrial RNA processing defects, leading to type I interferon signaling upregulation through mt-dsRNA accumulation.

ARF1 prevents aberrant type I IFN induction by regulating STING activation and recycling

This study identifies ARF1 as a negative regulator of cGAS-STING signaling, showing it prevents type I IFN induction by regulating STING activation and recycling.

ECSIT prevents Alzheimer's disease pathology by regulating neuronal mitochondrial ROS and mitophagy

This study shows that ECSIT regulates neuronal mitochondrial ROS and mitophagy, and its reduction contributes to Alzheimer's disease pathology.