Structural and biochemical characterization of the ALX4 dimer reveals novel insights into how disease alleles impact ALX4 function
Brittany Cain, Zhenyu Yuan, Evelyn Thoman, Rhett A. Kovall, Brian A. Gebelein
This study characterizes the ALX4 dimer structure and shows how disease variants disrupt its cooperativity and DNA binding specificity.
Nature Communications · May 23, 2025Peer-reviewedMolecular Biology