Rhett A. Kovall

This study shows that SLC25A3-mediated copper transport to mitochondria is essential for skeletal myoblast differentiation and survival of mature myotubes.

This study characterizes the ALX4 dimer structure and shows how disease variants disrupt its cooperativity and DNA binding specificity.

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

This study investigates how Gsx2 binds DNA cooperatively, revealing structural and thermodynamic mechanisms underlying its dimeric DNA binding and specificity.

The paper shows that Notch dimerization is crucial for intestinal homeostasis, with HDAC2 activity modulating Notch function in intestinal stem cells.

This study uses a Drosophila Su(H) model to show that AOS-linked RBPJ variants cause developmental defects by sequestering Notch cofactors, leading to dysregulated target gene expression.

The paper shows that enhancers with SPS sites are more resistant to repression by Hairless co-repressor compared to those with CSL sites.

The paper shows that an enhancer with specific binding sites can induce Notch haploinsufficiency phenotypes in Drosophila with wild-type Notch gene dose by promoting rapid Notch turnover through a bind and discard mechanism.

This study shows that Notch dimerization is critical for intestinal homeostasis and immune responses, with mite infestation worsening related phenotypes and triggering lymphoma in mutant mice.