Brittany Cain

The paper identifies 11 rules governing cooperativity in Paired-like homeodomain DNA binding and shows how disease variants disrupt this cooperativity.

This study characterizes the ALX4 dimer structure and shows how disease variants disrupt its cooperativity and DNA binding specificity.

This study investigates how Gsx2 binds DNA cooperatively, revealing structural and thermodynamic mechanisms underlying its dimeric DNA binding and specificity.

The paper shows that enhancers with SPS sites are more resistant to repression by Hairless co-repressor compared to those with CSL sites.

The paper shows that an enhancer with specific binding sites can induce Notch haploinsufficiency phenotypes in Drosophila with wild-type Notch gene dose by promoting rapid Notch turnover through a bind and discard mechanism.

The paper shows that Gsx2 and Ascl1 physically interact in the mouse lateral ganglionic eminence, inhibiting Ascl1-driven neurogenesis and promoting progenitor expansion.