Brian A. Gebelein

The paper identifies 11 rules governing cooperativity in Paired-like homeodomain DNA binding and shows how disease variants disrupt this cooperativity.

The paper identifies two distinct temporal roles for GLI3 in neural crest development: one in early specification and another in cranial NCC differentiation.

The paper introduces a model linking chromatin and enhancer states to transcriptional bursting dynamics, using the Monod-Wyman-Changeux framework to predict bursting behavior in C. elegans.

This study characterizes the ALX4 dimer structure and shows how disease variants disrupt its cooperativity and DNA binding specificity.

This study uses a Drosophila Su(H) model to show that AOS-linked RBPJ variants cause developmental defects by sequestering Notch cofactors, leading to dysregulated target gene expression.

The paper shows that enhancers with SPS sites are more resistant to repression by Hairless co-repressor compared to those with CSL sites.

This study shows Gli3 and Hand2 work together to control gene expression in craniofacial development without relying on a graded Hh signal.

The paper shows that an enhancer with specific binding sites can induce Notch haploinsufficiency phenotypes in Drosophila with wild-type Notch gene dose by promoting rapid Notch turnover through a bind and discard mechanism.

The paper shows that Gsx2 and Ascl1 physically interact in the mouse lateral ganglionic eminence, inhibiting Ascl1-driven neurogenesis and promoting progenitor expansion.

This study shows that Notch dimerization is critical for intestinal homeostasis and immune responses, with mite infestation worsening related phenotypes and triggering lymphoma in mutant mice.

This study investigates how abdominal Hox factors regulate distinct cis-regulatory elements in Drosophila by comparing activation and repression mechanisms.