Seeding patient-derived tau induces tauopathy-specific aggregation and lysosomal disruption in human cells
Tomas Kavanagh, Aysha Y. G. Strobbe, Kaleah Balcomb, Charleigh T. A. Agius, Jingting Gao, Sian Genoud, Evgeney Kanshin, Beatrix M. Ueberheide, Michael Kassiou, Eryn L. Werry, Glenda Margaret Halliday, Eleanor Drummond
This study uses patient-derived tau aggregates to induce disease-specific tauopathy features in human cells, revealing distinct pathological responses across tau strains.
bioRxiv · Apr 21, 2026 · PreprintCell Biology