Tomas Kavanagh

Transcriptome-Wide Alternative Splicing Analysis Implicates Complex Events in Bipolar Disorder

This study performs a transcriptome-wide alternative splicing analysis in bipolar disorder, identifying complex splicing events and candidate genes associated with the disorder.

Seeding patient-derived tau induces tauopathy-specific aggregation and lysosomal disruption in human cells

This study uses patient-derived tau aggregates to induce disease-specific tauopathy features in human cells, revealing distinct pathological responses across tau strains.

Polyanionic peptibody ameliorates tau pathology and promotes neuronal proteostasis in a tau transgenic mouse model

This study develops a polyanionic peptibody, ACR12, that reduces tau aggregation and restores neuronal protein levels in a tau transgenic mouse model.

FAMILY-BASED RNA SEQUENCING IN BIPOLAR DISORDER FOR CANDIDATE GENE AND PATHWAY IDENTIFICATION

This study uses RNA sequencing in multiplex bipolar disorder families to identify differentially expressed genes and pathways, finding significant lncRNAs and ion homeostasis dysregulation.

Compilation of all known protein changes in the human Alzheimer's disease brain

The paper compiles and analyzes proteomic data from 38 Alzheimer's disease studies to create a database of protein changes in human brain tissue across disease stages and regions, revealing patterns of protein dysfunction.