Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role
Evodie Koutouan, Alejandro Lillo, Ayano Kabashima, Jack W. Sample, Danielle Marie Carlson, Rondell Patrell Graham, Rory L. Smoot, Elena Bianca Pasquale
The paper identifies frequent EPHA2 mutations in cholangiocarcinoma and shows they disrupt forward signaling, suggesting EPHA2 acts as a tumor suppressor.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · Nov 3, 2025Peer-reviewedBiochemistry